Take a look at some FBI Ballistics stats...and read a few posts by Massad Ayoob and you might be swayed--the 'Myth' about 45acp being the end all be all self-defense round is not drawn on anything more than opinion....
Mr. Ayoob is considered to by many to be THE author about defensive handgunning tactics and training...and his advice has always been handgun selection based upon 1)reliability...its an HK so you are covered! 2) concealability and comfort....if the gun is too bulky or heavy then you are less likely to carry it....3) controllability...can you accurately control both calibers? Can you afford to shoot it enough for proficiency?
These primary factors might help sway your decision....I personally went with a USPc LEM in .40 because I simply couldn't conceal a .45...and I am CERTAIN it will stop a threat just as effectively as a .45acp...
Best of luck and hope it helps! Make sure to let us know what you go with....



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