The 45C is a great handgun - very repeatable at 15 and 25 yards. No problems with 185g Remington FMJ either. I picked up a Comp-Tac belt holster - I don't carry a lot, but it's great secure holster at the range. I honestly can't think of a better home defense pistol.
I also always do a decock on a handgun I'm not experienced with at the range first before I do it anywhere else - just my paranoia I guess.